GLUCOSE & INSULIN RESISTANCE
Her A1C was 5.7. "That's pre-diabetic, but not diabetes yet.
She was told to watch her sugar and come back in a year.
By the time A1C reaches 5.7, insulin resistance has likely been building for years. This number is a lagging indicator. The metabolic shift started well before it showed up on paper.
I don't reflexively check fasting insulin. The measurement varies with timing, stress, and lab processing, and there's no standardized reference range. It sounds useful. In isolation, it isn't.
What I look at instead: A1C trend over time. Triglyceride-to-HDL ratio (optimal below 1.5, acceptable below 2). The clinical picture: weight gain around the midsection, fatigue after meals, afternoon crashes. The pattern tells me more than a single number.
Her fasting glucose was 102. Three years earlier it had been 92. Last year, 98. That trajectory was the signal. Not the number.
I look at this alongside A1C, lipid panel, and body composition. Address it early and the trend is reversible. Wait until it hits 126, and it's a harder conversation.